Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-867-7 | CAS number: 75-38-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, comparable to guideline; minor restrictions in design and/or reporting but otherwise adequate for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1-difluoroethylene
- EC Number:
- 200-867-7
- EC Name:
- 1,1-difluoroethylene
- Cas Number:
- 75-38-7
- Molecular formula:
- C2H2F2
- IUPAC Name:
- 1,1-difluoroethene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 200,000 ppm
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Animals were observed for 7 days after exposure.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LCLo
- Effect level:
- > 200 000 ppm
- Exp. duration:
- 1 h
- Remarks on result:
- other: Animals were observed for 7 days after exposure, no effects were noted
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No respiratory and skeletal reflex changes were observed. The animals remained alert and responsive to environmental stimuli.
- Body weight:
- No loss in body weight was observed.
- Gross pathology:
- No gross pathological changes were observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
