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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List VI
Author:
Smyth H.F. et al.
Year:
1962
Bibliographic source:
Am Ind Hyg Assoc J. 1962 Mar-Apr;23:95-107

Materials and methods

Principles of method if other than guideline:
Inhalation Risk Test, where animals were exposed to a flowing stream of saturated vapour for up to 8 hours. The inhalation period is defined by killing half of the animals within a 14 day recovery period.
GLP compliance:
no
Test type:
other: Inhalation Risk Test (IRT)
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Octanoic acid
EC Number:
204-677-5
EC Name:
Octanoic acid
Cas Number:
124-07-2
IUPAC Name:
octanoic acid
Details on test material:
- Name of test material (as cited in study report): Octanoic Acid (mixed isomers)

Test animals

Species:
rat
Strain:
other: Albino
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: dried room air
- System of generating vapour: by passing 2.5 L/minute dried room air through a fritted glass disc immersed to a deep at least 1 inch in approx. 50 ml of test substance contained in a gas-washing bottle
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
0.1621 mg/l (Danish EPA QSAR database, 2004 )
No. of animals per sex per dose:
6 males or females
Control animals:
other: analogue tests with other substances were also reported
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 0.162 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: vapour

Applicant's summary and conclusion