Palmitic acid

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented publication which meets basic scientific principles

Data source

Reference

Reference Type:

publication

Title:

Range-finding toxicity data: List VI

Author:

Smyth H.F. et al.

Year:

1962

Bibliographic source:

Am Ind Hyg Assoc J. 1962 Mar-Apr;23:95-107

Materials and methods

Principles of method if other than guideline:

Inhalation Risk Test, where animals were exposed to a flowing stream of saturated vapour for up to 8 hours. The inhalation period is defined by killing half of the animals within a 14 day recovery period.

GLP compliance:

no

Test type:

other: Inhalation Risk Test (IRT)

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Octanoic acid

EC Number:

204-677-5

EC Name:

Octanoic acid

Cas Number:

124-07-2

IUPAC Name:

octanoic acid

Details on test material:

- Name of test material (as cited in study report): Octanoic Acid (mixed isomers)

Test animals

Species:

rat

Strain:

other: Albino

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: dried room air
- System of generating vapour: by passing 2.5 L/minute dried room air through a fritted glass disc immersed to a deep at least 1 inch in approx. 50 ml of test substance contained in a gas-washing bottle

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

4 h

Concentrations:

0.1621 mg/l (Danish EPA QSAR database, 2004 )

No. of animals per sex per dose:

6 males or females

Control animals:

other: analogue tests with other substances were also reported

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 0.162 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: vapour