Registration Dossier
Registration Dossier
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EC number: 208-863-7 | CAS number: 544-17-2
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Remarks:
- other: in vitro
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment. Sodium formate caused adverse effects only at high concentrations. Relevance of the in-vivo situation is unclear.
Data source
Reference
- Reference Type:
- publication
- Title:
- Histopathologic approaches to chemical toxicity using primary cultures of dissociated neural cells grown in chamber slides.
- Author:
- Bolon B, Dorman DC, Bonnefol MS, Randall HW, and Morgan KT
- Year:
- 1 993
- Bibliographic source:
- Toxicologic Pathology 21, 465-479.
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium formate
- EC Number:
- 205-488-0
- EC Name:
- Sodium formate
- Cas Number:
- 141-53-7
- Molecular formula:
- CHO2Na
- IUPAC Name:
- sodium formate
- Details on test material:
- Sodium formate.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
Results and discussion
Any other information on results incl. tables
Neurotoxic effects seen with sodium formate after 8 h of
incubation:
1) Toxicity in developing cultures:
Sodium formate: toxic at </= 40 mM.
Toxicity of model toxicants:
Cytosine arabinoside: gliotoxic at 0.01 mM.
2) Mature cultures
Sodium formate: neuronotoxic at </= 60 mM.
cytotoxic at >/= 120 mM.
Toxicity of model toxicants:
Glutamate neuronotoxic at </= 5.0 mM;
Methyl iodide neuronotoxic at </= 2.50 mM
cytotoxic at >/= 5.0 mM.
Sodium formate caused lesions mainly in large, polygonal
neurons.
Applicant's summary and conclusion
- Conclusions:
- Neuronotoxicity in vitro seen at >/= 40 mM sodium formate
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