Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Unsuitable test system. Route of exposure not to be considered for assessment.

Data source

Reference
Reference Type:
publication
Title:
Die akute und chronische Toxizität der Ameisensäure und ihrer Formiate.
Author:
Malorny G
Year:
1969
Bibliographic source:
Zeitschrift Ernährungswissenschaft 9, 332-339.

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium diformate
EC Number:
208-863-7
EC Name:
Calcium diformate
Cas Number:
544-17-2
Molecular formula:
CH2O2.1/2Ca
IUPAC Name:
calcium diformate
Test material form:
solid: particulate/powder

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intravenous
No. of animals per sex per dose:
55

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
154 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
LD50 of formic acid and its salts in the mouse following
i.v. injection:

===========================================================
Substance      LD50      range        LD50           No. of
                                    (formate #)     animals
                 (mg/kg bw)         (mg/kg bw)          n
-----------------------------------------------------------
Formic acid    145      138-151        142             50
Na-formate     807      800-813        534             50
K-formate       95       93-97          51             55
NH4-formate    410      408-412        293             50
Ca-formate     154      150-158        107             55 
===========================================================
# = calculated proportion of formate of the LD50 dose.

Applicant's summary and conclusion

Conclusions:
The LD50 of calcium formate was 154 mg/kg bw in mice following i.v. injection.