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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Methyl acetate need not to be classified as toxic to fish

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
250 mg/L

Additional information

In a 96-h acute toxicity study according to OECD 203, zebra fish (Brachidanio rerio) were exposed to methyl acetate at nominal concentrations of 0, 100, 250, 350, 500, 1000, 1800 and 5000 mg a.i./L} under static conditions.  The 96-h LC50was 250 - 350 mg a.i./L.  The LC0and LC100values, based on mortality, were 250 and 500 mg a.i./L, respectively.  Sublethal effects of protruding gills, increased and decreased breathing, passive sinking, swimming at the surface, increased and decreased activity, edema, tremours, convulsions were observed in the groups exposed to 350, 500, 1000, 1800, and 5000 mg a.i./L. 

The 96-h LC50was 250 - 350 mg a.i./L. The lower value is given as key value.

LC50 for marine fish is not available.