Methyl acetate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Source EU risk assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1962

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Concentrated vapor inhalation consists of exposing 6 male or female albino rats to a following stream of vapor-ladened air. The vapor-air mixture is generated by passing 2.5L /minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 ml of the test chemical contained in a gas-washing bottle. Inhalations are continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation period killing about half the number of rats within 14 days is defined. Inhalation of metered vapor concentrations by rats is conducted with flowing streams of vapor prepared by various styles of proportioning pumps. Inhalation periods are usually four hours' duration unless slight toxicity enforces an eight hour period. Concentration recorded are nominal and not analytically verified. They are in an essentially logarithmic series with a factor of two, and the Table records the concentration yielding fractional mortaility among 6 rats within 14 days. Where no fractional mortality was observed, usually both the concentration yielding no mortality and that yielding complete mortality are indicated.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methyl acetate

EC Number:

201-185-2

EC Name:

Methyl acetate

Cas Number:

79-20-9

Molecular formula:

C3H6O2

IUPAC Name:

methyl acetate

Test animals

Species:

rabbit

Strain:

other: albino

Sex:

male/female

Details on test animals or test system and environmental conditions:

Not available

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

4 h

Concentrations:

16,000 ppm
32,000 ppm

No. of animals per sex per dose:

6

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Key result

Dose descriptor:

LC0

Effect level:

49.2 mg/L air

Exp. duration:

4 h

Effect levels 2

Dose descriptor:

LC100

Effect level:

98.4 mg/L air

Exp. duration:

4 h

Any other information on results incl. tables

49.2 mg/l < LC50< 98.4 mg/l

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Executive summary:

Smyth et al screened industrial chemicals for acute toxicity values. For methylacetate the following values were determined.

LC0 = 49.2 mg/l/4h

LC50 > 49.2 mg/l/4h