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Toxicological information

Basic toxicokinetics

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Administrative data

basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Insufficient information provided on methods and results to accurately evaluate the study; no guideline available.
Reason / purpose for cross-reference:
reference to other study

Data source

Reference Type:
Distribution of Tungsten in the Rat Following Ingestion of Tungsten Compounds.
Kinard FW and Aull JC.
Bibliographic source:
Journal of Pharmacology And Experimental Therapeutics, Vol. 83, Issue 1, 53-55.

Materials and methods

Objective of study:
Test guideline
no guideline followed
Principles of method if other than guideline:
Distribution of tungsten in various organs of the rat following oral ingestion of tungsten compounds.
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
Ammonium wolframate
EC Number:
EC Name:
Ammonium wolframate
Cas Number:
Molecular formula:
Ammonium (para)tungstate
Constituent 2
Reference substance name:
Ammonium paratungstate
Ammonium paratungstate
Details on test material:
- Name of test material (as cited in study report): Ammonium paratungstate

Test animals

not specified
Details on test animals or test system and environmental conditions:
Thirty-seven day old rats were placed on a basal diet of ground purina dog chow in which the finely ground tungsten compounds had been incorporated. For each experimental diet, 2 female and 2 male rats were used with the sexes separately caged. Diet and water were given ad libitum.

Administration / exposure

Route of administration:
oral: feed
unchanged (no vehicle)
Details on exposure:
For each experimental diet, 2 female and 2 male rats were used.
Duration and frequency of treatment / exposure:
Approximately 100 days.
Doses / concentrations
Doses / Concentrations:
Diet D: 0.6912 percent Ammonium paratungstate (0.5 per cent W) in Purina dog chow.
No. of animals per sex per dose / concentration:
2 females and 2 males
Control animals:
yes, concurrent no treatment
Positive control reference chemical:
Details on study design:
The tissues of both rats of each sex on the same diet were combined, weighed, rinsed free of blood, and prepared for analysis. The method of Aull and Kinard was used for the determination of the tungsten.
Details on dosing and sampling:
PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: brain, heart, uterus, lung, muscle, testis, blood, kidney and liver
no data

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on distribution in tissues:
No traces of tungsten were found in the heart, uterus, or brain of females. A trace amount of tungsten was found in the brain of males. No relation was observed between diet or sex and the presence or absence of tungsten in the lungs, muscle, or testis. Trace amounts of tungsten were found in the blood and liver of both male and female rats, and kidneys of male rats and 2 mgm of tungsten was found in the kidneys of female rats. Nine and 10 mgm percent tungsten was found in the bone of male and female rats respectively. Two and 9 mgm weight tungsten was found in the skin of male and female rats respectively. Trace amounts of tungsten were found in the male spleen while 10 mgm where found in the female spleen.

Metabolite characterisation studies

Metabolites identified:
not measured

Any other information on results incl. tables

In no instance was there any trace of tungsten found in the animals kept on the control diet.

Applicant's summary and conclusion