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EC number: 234-364-9 | CAS number: 11120-25-5
Toxicological information
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-02-24 to 1999-06-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Well documented, scientifically sound study that was conducted in accordance to GLP and OECD guideline 401 with no deviation to the protocol.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ammonium wolframate
- EC Number:
- 234-364-9
- EC Name:
- Ammonium wolframate
- Cas Number:
- 11120-25-5
- Molecular formula:
- (NH4)10H2W12O42*4H2O
- IUPAC Name:
- Ammonium (para)tungstate
- Reference substance name:
- Ammonium paratungstate
- IUPAC Name:
- Ammonium paratungstate
- Details on test material:
- - Name of test material (as cited in study report): Ammonium paratungstate (CAS# as cited in study: 12028-06-7)
- Physical state: White powder
- Analytical purity: >99.9%
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, England
- Age at study initiation: 4 to 7 weeks
- Weight at study initiation: 80 to 108 g
- Fasting period before study: Access to food only was prevented overnight prior to and for approximately 4 hours after dosing.
- Housing: Housed in groups of 5 rats of the same sex in metal cages with wire mesh floors.
- Diet: Special Diet Services RM1(E) SQC expanded pellet- ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 to 22.5
- Humidity (%): 29 to 52%
- Air changes (per hr): 10 to 15
- Photoperiod (hrs dark / hrs light): 12/12 artificial light (0700 - 1900)
IN-LIFE DATES: From: 1998-02-24 To: 1998-03-10
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% w/v aqueous methylcellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% w/v in 1% w/v aqueous methylcellulose
MAXIMUM DOSE VOLUME APPLIED :- 2000 mg/kg bodyweight - Doses:
- 2000 mg/kg bodyweight; administered at a dose volume of 10 mL/kg bodyweight.
- No. of animals per sex per dose:
- 5 males and 5 females.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: All surviving animals were killed on Day 15
- Mortality: Cages were checked at least twice daily for any mortalities.
- Clinical signs: Animals were observed soon after dosing and at frequent intervals for the remainder of Day 1. On subsequent days animals were observed once in the morning and again at the end of the experimental day (with exception of Day 15 - morning only). The nature and severity of the clinical signs and time were recorded at each observation.
- Bodyweight: Recorded on Days 1 (prior to dosing), 8 and 15. Individual weekly bodyweight changes and group mean bodyweights were calculated.
- Microscopic pathology: All animals were subjected to a macroscopic examination which consisted of opening the thoracic and abdominal cavities. The macroscopic appearance of all examined organs was recorded. - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths in a group of ten rats (five males and five females ) following a single oral dose of Ammonium paratungstate at a dosage of 2000 mg/kg bodyweight.
- Clinical signs:
- other: Piloerection was observed in all rats within five minutes of dosing. This persisted and was accompanied on Day 1 only by hunched posture and abnormal faeces (characterised by soft to liquid and discoloured yellow/brown mucoid faeces), seen in all rats and
- Gross pathology:
- No macroscopic abnormalities were observed for animals killed at study termination on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute lethal oral dose to rats of ammonium wolframate was demonstrated to be greater than 2000 mg/kg bodyweight.
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