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EC number: 234-364-9 | CAS number: 11120-25-5
Toxicological information
Skin irritation / corrosion
Currently viewing:
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-02-25 to 1998-02-28 28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Well documented, scientifically sound study that was conducted in accordance to GLP and OECD guideline 404 with no deviation to the protocol.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ammonium wolframate
- EC Number:
- 234-364-9
- EC Name:
- Ammonium wolframate
- Cas Number:
- 11120-25-5
- Molecular formula:
- (NH4)10H2W12O42*4H2O
- IUPAC Name:
- Ammonium (para)tungstate
- Reference substance name:
- Ammonium paratungstate
- IUPAC Name:
- Ammonium paratungstate
- Details on test material:
- - Name of test material (as cited in study report): Ammonium Paratungstate (CAS# as cited in study: 12028-06-7)
- Physical state: White powder
- Analytical purity: >99.9%
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd Bicester, Oxon, England
- Age at study initiation: 10 to 11 weeks
- Weight at study initiation: 2.2 to 2.6 kg
- Housing: Individually in metal cages with perforated floors
- Diet (eg ad libitum): STANRAB (P) SQC Rabbit Diet- ad libitum
- Water (eg ad libitum): ad libitum
- Acclimation period: Acclimated, but period not stated.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 22.5
- Humidity (%): 39 to 56%
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12/12 artificial light (0700 - 1900)
IN-LIFE DATES: From: 1998-02-25 To: 1998-02-28
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g of the test substance was applied under a 25 mm x 25 mm gauze pad.
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 mL distilled water - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: Approximately 24 hours prior to application of the test substance, hair was removed with electric clippers from the dorso-lumbar region of each rabbit exposing an area of skin approximately 100 mm x 100 mm.
- Type of wrap if used: Semi-occlusive dressing and gauze pad.
- Each treatment site was covered with "Elastoplast" elastic adhesive dressing for four hours. The animals were not restrained during the exposure period and were returned to their cages immediately after treatment. At the end of the exposure period, the semi-occlusive dressing and gauze pad were removed and the treatment site was washed.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Washed with warm water (35 °C) and area blotted dry with absorbent paper.
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Local dermal irritation was scored according to Draize.
CLINICAL SIGNS:
All animals were observed daily for signs of ill health or toxicity.
DERMAL RESPONSES:
Examination of the treated skin was made on Day 1 (ie approximately 60 minutes after removal of the dressings) and on Days 2, 3, and 4 (equivalent to 24, 48 and 72 hours after exposure).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- mean score for all 3 male rabbit
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No erythema
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- mean score for all 3 male rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- No edema
- Irritant / corrosive response data:
- No dermal response to treatment was observed in any animal throughout the study.
- Other effects:
- There were no signs of toxicity or ill health in any rabbit during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A single semi-occlusive application of ammonium paratungstate to intact rabbit skin for four hours elicited no dermal irritation.
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