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Description of key information

No indication of an estrogenic effect was observed in juvenile rats (CIT 1999).

Additional information

The study was performed according to the principles of GLP, but prior to establishment of a standard procedure (CIT 1999). No specific attention was paid to phytoestrogen levels in the diet. Groups of 6 juvenile female rats received a single dose of up to 1000 mg/kg bw of the substance in 0.5% methylcellulose on five consecutive days. 24 hours after the last dose the animals were sacrificed and uteri were dissected weighed. No changes in body weight and no changes in the wet uterus weight were observed. From these results, there is no evidence of an uterotrophic response.