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EC number: 250-709-6 | CAS number: 31570-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Animals fasted overnight were treated intraperitoneally, with a single dose. Physical condition and rate of deaths were monitored throughout the whole observation period.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Tris(2,4-ditert-butylphenyl) phosphite
- EC Number:
- 250-709-6
- EC Name:
- Tris(2,4-ditert-butylphenyl) phosphite
- Cas Number:
- 31570-04-4
- Molecular formula:
- C42H63O3P
- IUPAC Name:
- tris(2,4-ditert-butylphenyl) phosphite
- Details on test material:
- - Substance type: organic- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAIf
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CIBA-GEIGY Limited, Basle, Switzerland
- Age at study initiation: no data
- Weight at study initiation: 186-208g
- Fasting period before study: overnight
- Housing: in groups of 5 in Macrolon cages (type 3) individually marked with picric acid (During the treatment and observation period)
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2°C
- Humidity (%): 55 ± 10%
- Photoperiod (hrs dark / hrs light): 12 hours light per day
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: distilled water containing 0.5% carboxymethylcellulose + 0.1% polysorbate 80
- Details on exposure:
- Animals fasted overnight were treated intraperitoneally, with a single dose
- Doses:
- 1000, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- only common effects in this type of study
- Body weight:
- normal body weight gain
- Gross pathology:
- No compound related gross organ changes were observed except for some adhesions and some pseudomembranes, which developed as a directreaction to the intraperitoneal injection.
Applicant's summary and conclusion
- Conclusions:
- The acute intraperitoneal LD50 of the test article in rats of both sexes observed over a period of 14 days is greater than 2000 mg/kg. The test material is therefore slightly toxic to the rat by this route of administration.
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