Registration Dossier
Registration Dossier
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EC number: 271-846-8 | CAS number: 68609-97-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets National standards method with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- Four albino rats were exposed to a saturated atmosphere (nominal concentration: 0.15 mg/l) for 7 hours at room temperature.
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
Test material
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Concentrations:
- saturated atmosphere (nominal concentration: 0.15 mg/l)
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 0.15 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: limited data
- Mortality:
- 0%
- Clinical signs:
- other: Moderate eye and nasal irritation was observed in all animals during the exposure
- Body weight:
- No adverse body weight changes
Applicant's summary and conclusion
- Conclusions:
- The 7 hour LC 50 > 0.15mg/l (a saturated atmosphere).
- Executive summary:
The exposure of 4 albino rats to the saturated atmosphere (nominal concentration (0.15 mg/l) for 7 hours at room temperature resulted in 100% survival. Moderate eye and nasal irritation was observed in all animals during the exposure.
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