Registration Dossier
Registration Dossier
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EC number: 232-051-1 | CAS number: 7784-18-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Aluminium fluoride was reported to have low acute toxicity to Selenastrum capricornutum in an OECD guideline study (Test No. 201). Slight growth inhibition was observed, which was reported to be most likely due to fluoride exposure. The relationship between inhibition and concentration was strongly influenced by the formation of fluoride complexes with constituents of the dilution water. Based on the results of the study, the 72-hour NOEC value for growth rate inhibition was determined to be 22.5% (v/v) (undiluted water phase of a loading of 1000 mg/L of AlF3), which was equivalent to 1.7 mg fluoride/L. In addition, the 72-hour EC10 for growth rate inhibition was determined to be 1.8 mg fluoride/L and the 72-hour EC50 and EC90 for growth rate inhibition both greater than 1.8 mg fluoride/L.
Key value for chemical safety assessment
Additional information
The potential of AlF3to inhibit the growth of algae was assessed in a study conducted in accordance with the OECD Guidelines for the Testing of Chemicals No. 201 and in compliance with GLP (Olsson, 2001). The study was performed in Selenastrum capricornutum (i.e., Pseudokirchneriella subcapitata) using a freshwater, static test system. To prepare the stock test solution, 1000 mg of AlF3 was added to 1 L of algal medium and stirred for 24 hours. Since the substance was only slightly soluble, the water phase from the mixture was set to 100% v/v. Algae were treated in triplicate for 72 hours with concentrations of 5.625, 11.25, 22.5, 45, and 90% v/v AlF3, where 100% v/v AlF3 was analytically confirmed to consist of 3.0 mg aluminium/L and 7.6 mg fluoride/L.
Slight growth inhibition was observed, which was reported to be most likely due to fluoride exposure. The relationship between inhibition and concentration was strongly influenced by the formation of fluoride complexes with constituents of the dilution water. The 72-hour NOEC for growth rate inhibition was determined to be 22.5% v/v AlF3, which is equivalent to 1.7 mg fluoride/L. In addition, the 72-hour EC10 for growth rate inhibition was determined to be 1.8 mg fluoride/L and the 72-hour EC50 and EC90 for growth rate inhibition both greater than 1.8 mg fluoride/L. The validity criteria for this test were fulfilled.
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