Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-051-1 | CAS number: 7784-18-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented, according to accepted guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Aluminium fluoride
- EC Number:
- 232-051-1
- EC Name:
- Aluminium fluoride
- Cas Number:
- 7784-18-1
- Molecular formula:
- AlF3
- IUPAC Name:
- aluminum trifluoride
- Details on test material:
- - Name of test material (as cited in study report): ALF, Aluminum fluoride (Chemical formula: ALF3)
- Physical state: solid
- Analytical purity: not reported
- Lot/batch No.: XP01_00008_01
- Expiration date of the lot/batch: Not reported
- Storage condition of test material: room temperature, in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar (ordered as SPF-status) of the stock Mol:WIST
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M & By Ejby, DK-4623 Lille Skensved, Denmark.
- Age at study initiation: not reported
- Weight at study initiation: 135-161 g
- Fasting period before study: overnight
- Housing: 2 or 3 animals per cage (transparent polycarbonate, macrolon type 111, floor area 810 cm²), males and females separated
- Diet (e.g. ad libitum): Altromin 131 4" from Chr. Petersen A/S, DK-4 100 Ringsted ad libitum
- Water (e.g. ad libitum): domestic quality drinking water acidified with HCl to pH 2.5 in order to prevent microbial growth ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 3 °C
- Humidity (%): 55 ± 15 %
- Air changes (per hr): 10/hr
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: From: 26 Jan. 2001 To: 09 Feb. 2001
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% CMC
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: not reported
- Amount of vehicle (if gavage): 10 mL/kg bw
- Justification for choice of vehicle: not reported
- Lot/batch no. (if required): not reported
- Purity: not reported
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- Sighting study: 500 and 2000 mg/kg bw
Main study: 2000 mg/kg bw - No. of animals per sex per dose:
- Sighting study: 1 female each at 500 and 2000 mg/kg bw
Main study: 5 animals/sex - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed at least 1, 3, and 6 hours after administration and daily thereafter; body weights recorded on days 1, 2, 3, 4, 8, and 15
- Necropsy of survivors performed: yes - Statistics:
- None performed. The LD50 was greater than the highest dose tested.
Results and discussion
- Preliminary study:
- Sighting study: 1 female rat was given 500 mg AlF3/kg body weight. Since no clinical signs of evident toxicity were observed in this rat, another female rat was given 2000 mg AlF3/kg body weight. No signs of evident toxicity were observed in this rat.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LDLo
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None of the animals died.
- Clinical signs:
- other: Sighting study: female receiving 500 mg/kg bw exhibited piloerection 1 and 3 hours after treatment with no other clinical signs of toxicity; female receiving 2000 mg/kg bw did not show any clinical signs of toxicity. Main study: piloerection was seen in
- Gross pathology:
- Post-mortem examinations revealed no abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
