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EC number: 931-038-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 12 FEB 1985 to 6 MAR 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given: comparable to guidelines Read-across hypothesis: for details please see read-across report in IUCLID section 13
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- : substance composition or purity not stated
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 112-44-7 + 19009-56-4
- IUPAC Name:
- 112-44-7 + 19009-56-4
- Reference substance name:
- n-Undecanal + 2-methyldecan-1-al
- IUPAC Name:
- n-Undecanal + 2-methyldecan-1-al
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: A. Tuck & Sons Limited, Battlesbridge, UK
- Age at study initiation: 4 to 6 weeks
- Weight at study initiation: males: 128-146 g, females: 127-139 g
- Fasting period before study: overnight
- Housing: in polypropylene cages with sawdust bedding in groups of five by sex
- Diet: standard laboratory rodent diet (Rat & Mouse Expanded Diet No. 1, Special Diet Services Limited, Witham, UK), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/- 3
- Humidity (%): 40-50
- Air changes (per hr): ~10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 6.08 mL/kg
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 0.5, 1, 2, 3, 4 and 5 hours following dosing; on subsequent days at least once
- Frequency of weighing: weekly (on day 0, 7, 14)
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: no animal died within the observation period
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Mortality:
- - no deaths occurred
- Clinical signs:
- other: - shortly after dosing: abnormal body carriage (hunched posture), lethargy, pilo-erection and a decreased respiratory rate - in some animals: diarrhoea and ptosis - recovery of all rats complete at day 3 (judged by external appearance and behaviour)
- Gross pathology:
- - in three rats congestion of the lungs only
- no macroscopic abnormalities seen in any of the remaining rats
Any other information on results incl. tables
Read-across justification: for details please see read-across report in IUCLID section 13
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the tested conditions, the substance does not reveal acute oral toxicity.
- Executive summary:
The test item (purity: not stated) was administered to 5 male and 5 female Sprague-Dawley albino rats by gavage at the limit dose of 5000 mg/kg bw according to testing guideline OECD 401. Following dosing minor clinical signs (as e.g. hunched posture, pilo-erection as well as diarrhoea or ptosis) occured, but were all reversible within 3 days. During the 14 days observation period no animal died. Subsequent gross pathology revealed congestions of the lungs in three rats, but no other macroscopic changes were seen. The given results lead to a LD0 = 5000 mg test item per kh bw (LD50 > 5000 mg/kg bw; Ruhrchemie AG/Safepharm, 1985).
This study was judged to be reliable with restrictions (RL2), due to the missing substance composition and purity.
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