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EC number: 200-848-3 | CAS number: 75-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1933
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimentelle Untersuchung über die Frage der Organschädigung nach Gasnarkose (Acetylen, Äthylen und Stickstoff)
- Author:
- Franken, H., Miklos, L.
- Year:
- 1 933
- Bibliographic source:
- Zentralblatt für Gynäkologie Nr 42, p. 2493-2498
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Possible organ damage from the administration of acetylene at anesthetic concentrations has been evaluated in rats, mice, guinea pigs, rabbits, and dogs. Animals were exposed to acetylene in oxygen for 0.5 - 2h per day for up to 93 days; no guideline available at that time
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Acetylene
- EC Number:
- 200-816-9
- EC Name:
- Acetylene
- Cas Number:
- 74-86-2
- Molecular formula:
- C2H2
- IUPAC Name:
- acetylene
- Test material form:
- other: gas
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- oxygen
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 0,5 - 2 h/d
- Frequency of treatment:
- daily up to 93 days
Doses / concentrations
- Dose / conc.:
- 25 000 ppm (nominal)
- Remarks:
- Doses / Concentrations:
25%
- No. of animals per sex per dose:
- 2 - 47
- Control animals:
- yes
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
Effect levels
- Key result
- Dose descriptor:
- NOAEC
- Effect level:
- 250 000 ppm
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- gross pathology
- Remarks on result:
- not determinable
- Remarks:
- no NOAEC identified
Target system / organ toxicity
- Key result
- Critical effects observed:
- not specified
Any other information on results incl. tables
In treated animals that survived to termination, no evidence of cellular injury to the parenchymatous cells of the heart, lungs, liver, kidneys, or spleen was reported. However, capillary hyperemia of the liver, kidneys and spleen was observed in some rats exposed to 25%. This effect was observed until at least the second day after the last exposure to the gas but was not evident in animals killed later (up to 5 days after the last exposure). Since capillary hyperemia was not observed in rats exposed to higher concentrations of acetylene, it does not appear to be test-material related.
Applicant's summary and conclusion
- Conclusions:
- Repeated exposure of rats to a concentration of 25% acetylene (1h/day for up to 93 days) did not cause any organ toxicity.
- Executive summary:
In a non-guideline subchronic inhalation toxicity study, acetylene was administered to 2 -47 rats/sex/concentration by whole body exposure at concentrations of 0 and 25,000 ppm daily for 1 hour for up to 93 days.
In treated animals that survived to termination, no evidence of cellular injury to the parenchymatous cells of the heart, lungs, liver, kidneys, or spleen was reported. However, capillary hyperemia of the liver, kidneys and spleen was observed in some rats exposed to 25%. This effect was observed until at least the second day after the last exposure to the gas but was not evident in animals killed later (up to 5 days after the last exposure). Since capillary hyperemia was not observed in rats exposed to higher concentrations of acetylene, it does not appear to be test-material related.
Based on the results of this study, the NOAEC is considered to be 25,000 ppm.
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