Registration Dossier
Registration Dossier
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EC number: 213-668-5 | CAS number: 999-97-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1993
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Only an summary table was available for review.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To investigate the acute toxicity of hexamethyldisilazane via the intraperitoneal route.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1,1,3,3,3-hexamethyldisilazane
- EC Number:
- 213-668-5
- EC Name:
- 1,1,1,3,3,3-hexamethyldisilazane
- Cas Number:
- 999-97-3
- Molecular formula:
- C6H19NSi2
- IUPAC Name:
- bis(trimethylsilyl)amine
- Details on test material:
- - Name of test material (as cited in study report): hexamethyldisilazane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 100-1600 mg/kg bw
- No. of animals per sex per dose:
- 10 (total)
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 800 mg/kg bw
Any other information on results incl. tables
Time of death: 2.5 hr to 3 days
Weight change over 2 weeks: 7+
Clinical signs: Moderately weak; prostration; tremor; twitching; rough coat; not mating.
Applicant's summary and conclusion
- Conclusions:
- In a tabulated summary of an acute intraperitoneal toxicity study (reliability score 4) the LD50 for 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3, EC 213-668-5) was 800 mg/kg bw.
- Executive summary:
In a tabulated summary of an acute intraperitoneal toxicity study (reliability score 4) the LD50 for 1,1,1,3,3,3-hexamethyldisilazane (CAS 999-97-3, EC 213-668-5)
was 800 mg/kg bw. Time to death was 2.5 hours to three days, and clinical signs were prostration, tremor, twitching, rough coat and 'not mating'.
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