Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
Route of exposure not relevant

Data source

Reference
Reference Type:
publication
Title:
Cyclosiloxanes produce fatal liver and lung damage
Author:
Lieberman et al.
Year:
1999
Bibliographic source:
Environmental Health Perspectives 107: 161-165

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
CD-1
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: soy oil
Doses:
no data
No. of animals per sex per dose:
No. of animals 5-12

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
other: acute intraperitoneal
Effect level:
6 000 - 7 000 mg/kg bw
Gross pathology:
At extremely high dose levels there were indications of liver and lung pathology as shown by clinical chemistry and histopathology studies.

Applicant's summary and conclusion