Registration Dossier
Registration Dossier
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EC number: 476-160-4 | CAS number: 54807-34-0
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The hydrolysis study has been performed on DMH (Dimethyl Hydantoin) and has been used for read-across purposes. The results of the study demonstrated that DMH was not hydrolyzed in aqueous media at a pH of 5 and 9. At a pH of 7 hydrolysis of DMH was minimal, resulting in very long half-lives. At pH 7, half-life is 3194 d in TRIS Buffer at 25°C and at pH 7 in HEPES Buffer 1715 d.
Key value for chemical safety assessment
Additional information
The hydrolysis study has been performed on DMH (Dimethyl Hydantoin) and has been used for read-across purposes.
The parent compound did not significantly hydrolyze in the pH range 5-9 as determined by thin layer and high performance liquid chromatography. The half-life of DMH was greater than 1700 days at pH7. Half-lives were notcalculated for pH5 and pH9 systems as positive slopes were obtained based on the linear regression analysis of the
data.
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