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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented and scientifically good. Not according to GLP nor to specific test guidelines.
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study
Principles of method if other than guideline:
A study was conducted to evaluate the skin irritation of the test material in rabbits. The rabbits were exposed to a single dose and observed during a period up to 72 hours
GLP compliance:
not specified
Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: firma Harlan
- Housing: individual cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 2
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12

Type of coverage:
open
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: same treatment applied to unshaved area
Amount / concentration applied:
no information
Duration of treatment / exposure:
up to 72 hours
Observation period:
24, 48 and 72 hours
Number of animals:
no information
Details on study design:
none
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48, 72h
Score:
0
Max. score:
4
Reversibility:
no data
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48, 72h
Score:
1
Max. score:
4
Reversibility:
no data
Irritant / corrosive response data:
none
Other effects:
none

none

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
This study reported that the test material 'Cenizas de cinc de segunda fusion' is not a skin irritant
Executive summary:

This study report demonstrated no skin irratation effect for the sample 'Cenizas de cinc de segunda fusion'

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented and scientifically good . Not according to GLP nor to specific test guidelines.
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study
Principles of method if other than guideline:
A study was conducted to evaluate the eye irritation of the test material in rabbits. The rabbits were exposed to a dose of 2.000mg/kg bw and observed during a period of 14 days
GLP compliance:
not specified
Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: firma Harlan
- Housing: individual cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 2
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Amount / concentration applied:
no information
Duration of treatment / exposure:
up to 72 hours
Observation period (in vivo):
24, 48 and 72 hours
Number of animals or in vitro replicates:
no information
Details on study design:
none
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48, 72h
Score:
0
Max. score:
4
Reversibility:
not specified
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24, 48, 72h
Score:
0
Max. score:
2
Reversibility:
not specified
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48, 72h
Score:
0
Max. score:
3
Reversibility:
not specified
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48, 72h
Score:
0
Max. score:
4
Reversibility:
not specified
Irritant / corrosive response data:
none
Other effects:
none

none

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
This study reported that the test material is not an eye irritant
Executive summary:

This study reported that the test material is not an eye irritant

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

An in vitro skin corrosion test demonstrate that the substance containing up to 6.65% chlorine content under the form of ZnCl or PbCl is not corrosive.

In vivo irritation tests (skin and eye) demonstrate no irritant effects.

Justification for classification or non-classification

An in vitro skin corrosion test demonstrate that the substance containing up to 6.65% chlorine content under the form of ZnCl or PbCl is not corrosive, so no classification is justified.

In vivo irritation tests (skin and eye) demonstrate no irritant effects, so no classification is justified for skin and eye irritation.