Registration Dossier
Registration Dossier
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EC number: 273-824-3 | CAS number: 69029-83-0 Residues remaining after refining and smelting of zinc from primary and secondary sources. Consists primarily of zinc compounds and may contain large amounts of iron and lead and their oxides as well as minor amounts of other metals and/or their compounds.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented and scientifically good. Not according to GLP nor to specific test guidelines.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
- Principles of method if other than guideline:
- A study was conducted to evaluate the skin irritation of the test material in rabbits. The rabbits were exposed to a single dose and observed during a period up to 72 hours
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Residues, zinc smelting
- EC Number:
- 273-824-3
- EC Name:
- Residues, zinc smelting
- Cas Number:
- 69029-83-0
- Molecular formula:
- Not available, UVCB substance.
- IUPAC Name:
- Residues, zinc melting, alloying and casting
- Details on test material:
- name of test substance: Cenizas de cinc de segunda fusion
origin of test substance: Befesa Zinc Amorebieta
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: firma Harlan
- Housing: individual cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 2
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- open
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: same treatment applied to unshaved area
- Amount / concentration applied:
- no information
- Duration of treatment / exposure:
- up to 72 hours
- Observation period:
- 24, 48 and 72 hours
- Number of animals:
- no information
- Details on study design:
- none
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- no data
- Irritant / corrosive response data:
- none
- Other effects:
- none
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This study reported that the test material 'Cenizas de cinc de segunda fusion' is not a skin irritant
- Executive summary:
This study report demonstrated no skin irratation effect for the sample 'Cenizas de cinc de segunda fusion'
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