Registration Dossier
Registration Dossier
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EC number: 204-823-8 | CAS number: 127-09-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: read-across from in vivo experimental test with an analogue
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The analogue Potassium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties for the skin irritation endpoint.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: read-across
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- Read-across approach from Letter of Access experimental data (test method similar to OECD 404) on the analogue Potassium Acetate.
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium acetate
- EC Number:
- 204-822-2
- EC Name:
- Potassium acetate
- Cas Number:
- 127-08-2
- IUPAC Name:
- potassium acetate
- Details on test material:
- - Name of test material (as cited in study report): Potassium acetate
- Molecular formula (if other than submission substance): C2H4O2.K
- Molecular weight (if other than submission substance): 98.142
- Smiles notation (if other than submission substance): [K+].[O-]C(C)=O
- InChl (if other than submission substance): 1/C2H4O2.K/c1-2(3)4;/h1H3,(H,3,4);/q;+1/p-1
- Structural formula attached as image file (if other than submission substance): see Fig. in attached report
- Analytical purity: 50,1% Potassium acetate
- Impurities (identity and concentrations): 0,10% Tolyltriazol; 0,05% H3PO4; rest water till 100%.
- Purity test date: 1990-07-16
- Lot/batch No.: Hoe CG 0255 OA ZD50 0001
- Storage condition of test material: 20 ºC
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 30-60 min
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 day
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 2 days
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 3 days
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 30-60 min
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 day
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 2 days
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 3 days
- Score:
- 0
- Max. score:
- 4
- Other effects:
- Based on the experimental results obtained with the analogue Potassium Acetate, which is considered to be not irritating for New Zealand White rabbits skin, and applying the read-across approach, the substance Sodium Acetate is also considered as not irritating under test conditions.
The analogue Potassium Acetate which shares the same functional group with Sodium Acetate, also has comparable values for the relevant molecular properties. These properties are:
- a low log Pow value which is -3.72 for Potassium Acetate and for Sodium Acetate,
- a similar water solubility which is 2.5 g/mL at 20 ºC for Potassium Acetate and 1.25 g/mL for Sodium Acetate at 25 ºC, and
- similar molecular weights which are 98.14 for Potassium Acetate and 82.03 for Sodium Acetate.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance Sodium Acetate is considered as not irritating under test conditions.
- Executive summary:
Based on the experimental results obtained (reported under the endpoint record 07.03.01_02 KAc) with the analogue Potassium Acetate, which is considered to be not irritating for New Zealand White rabbits skin, and applying the read-across approach, the substance Sodium Acetate is also considered as not irritating under test conditions.
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