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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study acceptable for assessment (short summary report available)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Further experience with the range finding test in the industrial toxicology laboratory.
Author:
Smyth HF and Carpenter CP
Year:
1948
Bibliographic source:
J. Ind. Hyg. Tox. 30: 63-68
Reference Type:
secondary source
Title:
Further experience with the range finding test in the industrial toxicology laboratory
Author:
Smyth H.F. und Carpenter C.P.
Year:
1948
Bibliographic source:
J. Ind. Hyg. Tox., 30, 63-68; cited in MAK Begruendung Methylacrylat (1985) (in German)

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity study in rabbits conducted according to the method described by Draize et al. (1944).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl acrylate
EC Number:
202-500-6
EC Name:
Methyl acrylate
Cas Number:
96-33-3
Molecular formula:
C4H6O2
IUPAC Name:
methyl prop-2-enoate
Details on test material:
- Name of test material (as cited in study report): Methyl acrylate
- Analytical purity: no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: MethyI "Cellosolve" solvent
Details on dermal exposure:
TEST SITE
- Type of wrap if used: rubber cuff application
Duration of exposure:
24 h
Doses:
no data
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 250 mg/kg bw
Remarks on result:
other: original data: LD50 = 1.3 mL/kg; calculated with a density of 0.96 g/mL
Mortality:
no data
Clinical signs:
other: no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU