Registration Dossier
Registration Dossier
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EC number: 202-500-6 | CAS number: 96-33-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles (restrictions: post-exposure observation period only 7 days, only one sex tested)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
- Principles of method if other than guideline:
- BASF Test
Several groups of 5 mice per dose were treated intraperitoneally with preparations of the test substance in 0.5 % traganth, respectively. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper. - GLP compliance:
- no
Test material
- Reference substance name:
- Methyl acrylate
- EC Number:
- 202-500-6
- EC Name:
- Methyl acrylate
- Cas Number:
- 96-33-3
- Molecular formula:
- C4H6O2
- IUPAC Name:
- methyl prop-2-enoate
- Details on test material:
- - Name of test material (as cited in study report): Acrylsaeuremethylester
- purity: unknown
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Roessling
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 0.5 % aqueous Traganth preparation
- Doses:
- 195, 302, 479, 759 and 1205 mg/kg bw
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 7 d
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 382 mg/kg bw
- Mortality:
- 1/5, 0/5, 4/5, 5/5 and 5/5 in the 195, 302, 479, 759 and 1205 mg/kg groups, respectively. Deaths occurred within 24 hours at the high doses, and up to 7 days at the lower doses.
- Clinical signs:
- Staggering, accelerated breathing, and seizures.
- Gross pathology:
- Necropsy did not reveal any pathological findings.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
