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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

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Description of key information

The half-life for hydrolysis of acetic anhydride was determined to be 4.4 mins at 25°C.

Key value for chemical safety assessment

Half-life for hydrolysis:
4.4 min
at the temperature of:
25 °C

Additional information

The hydrolysis study that has been cited in the IUCLID4 dataset (Gold, 1948) is suitable for use as weight of evidence but not as a key study. It is not GLP compliant and does not follow standard guidelines. The study reports rate constants at a range of temperatures but not at a range of pHs. Data has been generated using a QSAR (Episuite) and this has been used in conjunction with the data from Gold (1948) in a weight of evidence approach.