Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
dermal absorption, other
Remarks:
in chemico
Type of information:
(Q)SAR
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
Justification for type of information:
1. SOFTWARE
EPI Suite v. 4.11

2. MODEL (incl. version number)
DERMWIN v. 2.02

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
OC(=O)CCCCCCCCC(O)=O

Data source

Reference
Reference Type:
other:
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: REACH guidance on QSARs R.6
Version / remarks:
May/July 2008
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sebacic acid
EC Number:
203-845-5
EC Name:
Sebacic acid
Cas Number:
111-20-6
Molecular formula:
C10H18O4
IUPAC Name:
sebacic acid

Results and discussion

Percutaneous absorption
Absorption:
0.001 cm/h
Remarks on result:
not measured/tested
Remarks:
only in silico calculation available

Applicant's summary and conclusion

Conclusions:
The dermal absorption is regarded as low with an estimated Kp value of 0.00114 cm/hr.