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Carcinogenicity

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Description of key information

There are no specific test data available concerning carcinogenicity. However, sebacic acid (CAS 111-20-6), disodium sebacate (CAS 17265-14-4) or the structural analogue adipic acid (CAS 124-04-9) were not mutagenic in "in vitro" and "in vivo" assays. Furthermore, there is no evidence from chronic (six-months) repeated dose studies with disodium sebacate in two species (rat and rabbit) that the substance is able to induce hyperplasia and/or pre-neoplastic lesion. In a limited two-year chronic study in rats with the analogue substance adipic acid, no tumors were observed up to the highest tested concentration of 750 mg/kg bw/d for females and 3750 mg/kg bw/d in male rats. Consequently, and for the sake of animal welfare, the conduct of carcinogenicity testing is not warranted.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Additional information