Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-539-3 | CAS number: 62-53-3
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
The PNEC for secondary poisening has been derived from mammalian toxicity data.
Key value for chemical safety assessment
Additional information
Biomagnification of Aniline is not expected due to a): a low log Pow and b): low bioaccumulation factors as measured in fish and sediment organisms (see section 5.3). The dataset on mammalian toxicity is extensive and complete. Thus, these data can be used for hazard assessment purposes to estimate secondary poisoning.
In a repeated dose toxicity study with rats conducted over 104 weeks a LOAEL of 7 mg/kg bw/d was found. As no NOAEL is available, the PNECoral is derived from the LOAEL. This LOAEL have to be converted into a food concentration by using a conversion factor of 10. With this a LOEC of 70 mg/kg food can be derived. According to the TGD, for the calculation of the PNECoral an assessment factor of 30 has to be applied to this value based on a LOAEL found in a chronic study. Therefore, a PNECoral of 2.3 mg/kg food is calculated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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