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Determination of the hydrolysis as a function of pH is based on an examination of a change in the test substance concentration in buffers of various pH with time. That requires that a substance the hydrolysis of which is to be examined should be univocally defined, as pure as possible and, at the same time, sufficiently soluble in water, as it also states in the guideline (EU C.7): “This method is applicable only to water-soluble substances. Impurities may affect the results.”. It is obvious that the test substance is not well chemically defined, so the determination of what is the main component the hydrolysis of which should be examine and what are impurities is questionable. In addition all main components of the test substance are water insoluble (SiO2, Al2O3 and Fe2O3).

The free calcium oxide dissociates slowly in water into form calcium oxide and water. Calcium and hydroxide ions, or hydrogen and oxygen are naturally ubiquitous in the environment.