Registration Dossier
Registration Dossier
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EC number: 231-152-8 | CAS number: 7440-43-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- Only limited data are available on the skin sensitization potential of cadmium metal and cadmium compounds. Cadmium chloride did not show any skin sensitization effects at 0.5% in a GMPT test. Cadmium chloride and sulphate were patch-tested in human volunteers but, across several studies, the evidence remained inconclusive. If at all, significant exposure is expected to occur principally in occupational settings. Given the carcinogen properties of cadmium metal and some of the cadmium compounds, risk reduction measures are in place to prevent contact. Therefore, skin sensitization is not expected to be an issue for human health and further testing is not considered necessary, in accordance with Annex XI (3) of the REACH directive. This is in line with the conclusions of the EU Risk Assessment Report (RAR) (JRC, 2007).
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
