Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

skin sensitisation: in vitro
Data waiving:
other justification
Justification for data waiving:
Justification for type of information:
Only limited data are available on the skin sensitization potential of cadmium metal and cadmium compounds. Cadmium chloride did not show any skin sensitization effects at 0.5% in a GMPT test. Cadmium chloride and sulphate were patch-tested in human volunteers but, across several studies, the evidence remained inconclusive. If at all, significant exposure is expected to occur principally in occupational settings. Given the carcinogen properties of cadmium metal and some of the cadmium compounds, risk reduction measures are in place to prevent contact. Therefore, skin sensitization is not expected to be an issue for human health and further testing is not considered necessary, in accordance with Annex XI (3) of the REACH directive. This is in line with the conclusions of the EU Risk Assessment Report (RAR) (JRC, 2007).

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion