Pentaerythritol

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 2 to 3, 1993

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

yes

Remarks:

Translated report says "GLP Compatible"

Analytical monitoring:

not specified

Details on sampling:

No details

Vehicle:

no

Details on test solutions:

PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: direct dissolution in water

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: Daphnia magna
- Strain: not specified
- Source: National Institute for Environmental Studies of Environment Agency

- Method of breeding: not specified
- Feeding during test
- Food type: chlorella vulgaris
- Amount: 2x10^7 cells per feeding
- Frequency: once per day

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Post exposure observation period:

none specified

Hardness:

39 mg/L (reported as solidity). Alkalinity - 35 mg/L. Ca:Mg ratio = 2.8, Na:K ratio = 2.5

Test temperature:

19 +/-1 °C

pH:

Maintained at 7.6

Dissolved oxygen:

8.9 to 9.0 mg/L

Salinity:

Not applicable

Conductivity:

No details

Nominal and measured concentrations:

Control, 100, 180, 320, 560 and 1000 mg/L (nominal concentrations)

Details on test conditions:

TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:dechlorinated tap water

OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16 hurs light : 8 hours dark
- Light intensity: 500 lux

EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- immobilisation check after 24 hours exposure

TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8
- Range finding study
- Test concentrations: 0.1, 1.0, 10, 100 & 1000 mg/L
- Results used to determine the conditions for the definitive study:

Reference substance (positive control):

no

Key result

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

not specified

Basis for effect:

mobility

Duration:

24 h

Dose descriptor:

NOEC

Effect conc.:

1 000 mg/L

Nominal / measured:

nominal

Conc. based on:

not specified

Basis for effect:

mobility

Details on results:

No immobile Daphnia were observed in either the control or test treatments.

Results with reference substance (positive control):

not applicable

Reported statistics and error estimates:

Not applicable

Validity criteria fulfilled:

not specified

Conclusions:

The 24 hour EC50 for Daphnia magna exposed to pentaerythritol is greater than 1000 mg/L (the highest nominal exposure concentration tested). No immobility was observed during the study, therefore the corresponding no-observed effect concentration (NOEC) was 1000 mg/L.

Executive summary:

The 24 hour EC50 for Daphnia magna exposed to pentaerythritol is greater than 1000 mg/L (the highest nominal exposure concentration tested). No immobility was observed during the study, therefore the corresponding no-observed effect concentration (NOEC) was 1000 mg/L.

Description of key information

An experimental study which investigated the acute toxicity of pentaerythritol to Daphnia magnas howed no immobility of organisms in 1000 mg/L exposure concentrations of the test substance throughout the 24 hour exposure period. The 24 hour EC50 for D. magna exposed to pentaerythritol was therefore concluded to be >1000 mg/L (the highest nominal exposure concentration tested), therefore the corresponding no-observed effect concentration (NOEC) was 1000 mg/L (Fukuoka, 1993).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1 000 mg/L