Registration Dossier
Registration Dossier
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EC number: 273-760-6 | CAS number: 69012-63-1 By-product of refining of zinc ores consisting primarily of zinc, lead and iron.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented and scientifically good . Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute inhalation toxicity
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- project 10-04-0392/00-95, p5
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Flue dust, zinc-refining
- EC Number:
- 273-760-6
- EC Name:
- Flue dust, zinc-refining
- Cas Number:
- 69012-63-1
- Molecular formula:
- Not applicable - UVCB
- IUPAC Name:
- Zinc oxide enriched flue dust
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- Na-CMC 2% in aqua ad iniectabilia
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
- no deaths during the study
- no abnormal clinical signs observed
- weight gains normal
- gross pathological examinations at 14d p.a. (terminal necropsy) revealed no test article-dependent findings
- according to the requirements of the limit test, the LD50 values after 24h and 14d were: male and female > 2000mg/kg
- the above value is higher than the limit specified as harmful and the the test material is referred to as "non-toxic"
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- This acute toxicity test according to OECD 401 with Waelz zinc oxide demonstrated that the LC50 for rats was > 2000 mg/kg, and thus not classified for acute oral toxicity
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