Registration Dossier

Ecotoxicological information

Sediment toxicity

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Administrative data

Endpoint:
sediment toxicity: short-term
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Justification for type of information:
As the test substance does not dissolve in water, the mechanism of partitioning from the water phase and thus uptake by diffusion from the water phase does not take place. Thus exposure of sediment organisms to the test substance may occur only by oral intake of solid particles of the test substance. An effect in the organism would then be caused by internal partitioning of test substance (as modelled by equilibrium partitioning and for highly lipophilic substance with an additional factor of 10, see Guidance Document on Information Requirements and Chemical Safety Assessment R.10 and R.16). However, for activated carbon no absorption is expected (see toxicokinetic assessment). The absence of effects from oral intake of activated carbon is supported by the results of an acute toxicity study with rats where no adverse effects were observed after oral exposure to 2000 mg/kg (C80453). Thus there seems to be no justification in testing the effects of oral exposure of soil and sediment organisms. This is confirmed by the results of the reproduction toxicity test with earthworms (OECD 222), read across from Activated Carbon - High Density Skeleton, in which the NOEC was observed to be 1000 mg/kg soil. Therefore further testing with sediment organisms is waived

Data source

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EPA OPPTS 850.1790 (Chironomid Sediment Toxicity Test)
Deviations:
no

Results and discussion

Applicant's summary and conclusion