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EC number: 203-893-7 | CAS number: 111-66-0
Male Sprague-Dawley rats were acclimatized for 4 to 6 days prior to exposure. Animals were housed 4/ cage with the number of cages limited to 4 per exposure chamber. Food and water were givenad libitum, except during exposure period. Animals were exposed to individual hydrocarbons selected for the experiment in six different experiments. The approximate concentration of the hydrocarbons (1 -alkenes andiso-alkanes) tested was 100 parts per million. All exposures occurred during daytime for 12 hours for 3 consecutive days. Concentrations of the hydrocarbons was measured in blood, brain, liver, kidney and perirenal fat immediately after 12 hour exposure on each exposure day, and 12 hours after the last exposure had been completed. The animals were removed one at a time from the exposure chamber and killed by decapitation. A standard process, not described in the article, made it possible to obtain blood and organ samples within 3 minutes of removal of animals from the exposure chamber.
Experimental results indicated that 1-octene was efficiently absorbed in the blood with extensive accumulation in the organs compared to the iso-alkanes. Accumulation also was shown to increase with increasing carbon number. At day 3, concentrations of 1-octene were 12.4±0.5, 69.7±4.0, 78.9±9.7, 139.3±23.4, 720±176 μmol/kg in the blood, brain, liver, kidney, and fat, respectively. Concentrations of 1-decene were 16.4±1.1, 138.1±2.7, 192.8±13.5, 162±22.9, and 2986±305 μmol/kg at day 3 in the blood, brain, liver, kidney, and fat, respectively. Concentrations of the 1-alkenes remained high in the fat even after the 12 hour recovery period, with 226±85 μmol/kg of 1-octene and 1971±134 μmol/kg of 1-decene. According to the study authors, the extensive accumulation of 1-alkenes in the blood and organs when compared to other hydrocarbons may have toxicological significance and, therefore, products containing 1-alkenes should be handled cautiously to minimize inhalation exposure.
Based on study design and results, this study is classified as reliable with restrictions because while there is no statement regarding whether this study was conducted according to GLP or equivalent, the information provided indicates that this study was conducted in a manner similar to OECD 417 guideline.
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