Registration Dossier
Registration Dossier
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EC number: 204-211-0 | CAS number: 117-81-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity for rats and mice of di-2-ethylhexylphthalate with a note upon the mecanism.
- Author:
- Hodge HC
- Year:
- 1 943
- Bibliographic source:
- Proc Soc Exp Biol Med 53: 20-23
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral administration in rats by intraperitoneal route
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Bis(2-ethylhexyl) phthalate
- EC Number:
- 204-211-0
- EC Name:
- Bis(2-ethylhexyl) phthalate
- Cas Number:
- 117-81-7
- Molecular formula:
- C24H38O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) benzene-1,2-dicarboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 149-198g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 3100, 5700, 12700, 18100, 19200, 23800 mg/kg
- No. of animals per sex per dose:
- 5, 5, 5, 5, 15 and 15 rats in groups treated at 3100, 5700, 12700, 18100, 19200 and 2380 mg/kg respectively.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 5, 7 and 10 days
- Organ were weighted
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 23 800 mg/kg bw
- Remarks on result:
- other: intraperitoneal
- Mortality:
- No mortality was observed.
- Other findings:
- the average liver weights were 8.8, 7.8 and 7.3 g in animals killed 5 days, 7 days and 10 days after the injection, respectively.
Any other information on results incl. tables
| Nb of rats | Average body weight (g) | Dose (mg/kg) | Effects |
| 15 | 198 | 23800 | Diarrhea |
| 15 | 196 | 19200 | Some diarrhea |
| 5 | 155 | 18100 | - |
| 5 | 149 | 12700 | None |
| 5 | 159 | 5700 | None |
| 5 | 159 | 3100 | None |
Applicant's summary and conclusion
- Conclusions:
- Under these experimental conditions, the LD50 was estimated to be higher than 23800 mg/kg in rats by the intraperitoneal route.
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