Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
supporting study
Rationale for reliability incl. deficiencies:
other: A summary of direct observations data is provided in the Executive Summary.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Nickel dihydroxide
EC Number:
EC Name:
Nickel dihydroxide
Cas Number:
Molecular formula:
nickel(2+) dihydroxide

Results and discussion

Applicant's summary and conclusion

Executive summary:

Endpoint Summary:

Information describing exposure related observations were limited to a single study that was assigned as a K3 for reliability, thus data were generally insufficient to characterize this endpoint. During a clinical evaluation of male workers at an alkaline accumulator facility conducted by Friberg (1950), three workers died during the course of surveillance. The author partially attributed employment at the facility as a contributor to the reported health conditions in two of the three workers. However, given the uncertainty associated with these case studies (e.g., nickel (di)hydroxide exposure not evaluated, medical records not thoroughly evaluated, etc.), and the lack of other data, it is not possible to draw any meaningful conclusions regarding exposure related observations for nickel (di)hydroxide.