Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Adequacy of study:
supporting study
Rationale for reliability incl. deficiencies:
other: A summary of direct observations data is provided in the Executive Summary.

Data source

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Executive summary:

Endpoint Summary:

Information describing exposure related observations were limited to a single study that was assigned as a K3 for reliability, thus data were generally insufficient to characterize this endpoint. During a clinical evaluation of male workers at an alkaline accumulator facility conducted by Friberg (1950), three workers died during the course of surveillance. The author partially attributed employment at the facility as a contributor to the reported health conditions in two of the three workers. However, given the uncertainty associated with these case studies (e.g., nickel (di)hydroxide exposure not evaluated, medical records not thoroughly evaluated, etc.), and the lack of other data, it is not possible to draw any meaningful conclusions regarding exposure related observations for nickel (di)hydroxide.