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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
Not Reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference not available
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
review article or handbook
Title:
Nickel (II) hydroxide
Author:
NIOSH
Year:
2008
Bibliographic source:
In: Registry of Toxic Effects of Chemical Substances #QR7040000

Materials and methods

Principles of method if other than guideline:
Not Reported
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Nickel dihydroxide
EC Number:
235-008-5
EC Name:
Nickel dihydroxide
Cas Number:
12054-48-7
Molecular formula:
Ni(OH)2
IUPAC Name:
nickel(2+) dihydroxide
Details on test material:
Not Reported
- Name of test material (as cited in study report): Nickel (II) hydroxide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Not Reported

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Not Reported
Duration of exposure:
Not Reported
Doses:
Effect levles based on >2 g/kg; doses not reported
No. of animals per sex per dose:
Not Reported
Control animals:
not specified
Details on study design:
Not Reported
Statistics:
Not Reported

Results and discussion

Preliminary study:
Not Applicable
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 other: g/kg
Mortality:
Not Reported
Clinical signs:
other: Not Reported
Gross pathology:
Not Reported
Other findings:
Not Reported

Any other information on results incl. tables

Not Applicable

Applicant's summary and conclusion

Interpretation of results:
other: no data
Remarks:
Criteria used for interpretation of results: other: no data
Conclusions:
lethal dose (50 percent kill): >2g/kg
Executive summary:

Study rated by an independent reviewer.