Registration Dossier
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EC number: 235-008-5 | CAS number: 12054-48-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- Not Reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not available
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Nickel (II) hydroxide
- Author:
- NIOSH
- Year:
- 2 008
- Bibliographic source:
- In: Registry of Toxic Effects of Chemical Substances #QR7040000
Materials and methods
- Principles of method if other than guideline:
- Not Reported
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Nickel dihydroxide
- EC Number:
- 235-008-5
- EC Name:
- Nickel dihydroxide
- Cas Number:
- 12054-48-7
- Molecular formula:
- Ni(OH)2
- IUPAC Name:
- nickel(2+) dihydroxide
- Details on test material:
- Not Reported
- Name of test material (as cited in study report): Nickel (II) hydroxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not Reported
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Not Reported
- Duration of exposure:
- Not Reported
- Doses:
- Effect levles based on >2 g/kg; doses not reported
- No. of animals per sex per dose:
- Not Reported
- Control animals:
- not specified
- Details on study design:
- Not Reported
- Statistics:
- Not Reported
Results and discussion
- Preliminary study:
- Not Applicable
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 other: g/kg
- Mortality:
- Not Reported
- Clinical signs:
- other: Not Reported
- Gross pathology:
- Not Reported
- Other findings:
- Not Reported
Any other information on results incl. tables
Not Applicable
Applicant's summary and conclusion
- Interpretation of results:
- other: no data
- Remarks:
- Criteria used for interpretation of results: other: no data
- Conclusions:
- lethal dose (50 percent kill): >2g/kg
- Executive summary:
Study rated by an independent reviewer.
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