Registration Dossier
Registration Dossier
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EC number: 231-768-7 | CAS number: 7723-14-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A combined repeat dose toxicity study and reproductive / developmental toxicity screening study in rats was conducted (Huntingdon Life Sciences, 2012) to assess the effect of Fe3P on rats following repeated oral administration. The study was conducted according to OECD test guideline 422, and in compliance with GLP.
Male and female rats were administered Fe3P by oral gavage for five weeks (males, and toxicity phase females), or for two weeks before mating, during mating and gestation, and until day six of lactation (main phase females). The dose groups were 100, 300, and 1000 mg/kg/day, and a concurrent control group was administered with untreated vehicle.
Reproductive performance was not affected by treatment with test material; the assessed factors included mating performance, fertility and offspring survival. No adverse effects were seen on offspring development up to Day 7 of age.
On the basis of this study, the No Observed Adverse Effect Level for reproductive and developmental toxicity is considered to be 1000 mg/kg/day.
Short description of key information:
NOAEL, rat, oral exposure = 1000 mg/kg/day
Effects on developmental toxicity
Description of key information
NOAEL, rat, oral exposure = 1000 mg/kg/day
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Refer to fertility discussion for details.
Justification for classification or non-classification
In the above reproductive / developmental toxicity screening study, no effects whatsoever were observed on the reproduction of rats following repeated exposure to Fe3P, and no adverse effects were seen on the development of offspring. Therefore, Fe3P does not require classification for reproductive or developmental toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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