Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Biomonitoring data of workers from the rubber industry revealed 6PPD in urine, thereby demonstrating that the substance can be resorbed from the respiratory tract and possibly after dermal contact (Carlucci 1984, Rimatori and Castellino, 1989)

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

In an in vitro approach the hydrolysis rate and hydrolysis products of 6PPD in simulated gastric juice were evaluated (Monsanto Co. 1986a). During a 48-hours observation period 60 % of 6PPD was hydrolyzed. Based on the data obtained a hydrolysis rate of -0.0188 and a half-life of 36.9 hours were calculated. The approximate solubility of 6PPD in gastric juice was determined to be 173 mg/l. The major observed hydrolysis product was aniline. A trace of two intermediate hydrolysis products, benzoquinoneimine-N-phenyl, and N-1,3 dimethyl-butylamine p-phenol were detected.

There are no in vivo toxicokinetics studies of 6PPD available. However, some conclusions can be drawn from acute and repeated dose toxicity studies. The appearance of systemic toxicity after oral and dermal exposure shows the principal bioavailability of 6PPD via these routes.

Biomonitoring data of workers from the rubber industry revealed 6PPD in urine, thereby demonstrating that the substance can be resorbed from the respiratory tract and possibly after dermal contact (Carlucci 1984, Rimatori and Castellino, 1989)