Registration Dossier

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
Deviations:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: gas

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
other: Data available after Linde and Ikaria have been informed and granted permission
Toxicity:
no effects
Remarks:
Data available after Linde and Ikaria have been informed and granted permission
Vehicle controls validity:
other: Data available after Linde and Ikaria have been informed and granted permission
Negative controls validity:
other: Data available after Linde and Ikaria have been informed and granted permission
Positive controls validity:
other: Data available after Linde and Ikaria have been informed and granted permission

Any other information on results incl. tables

Data available after Linde and Ikaria have been informed and granted permission

Applicant's summary and conclusion