Registration Dossier
Registration Dossier
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EC number: 231-838-7 | CAS number: 7758-29-4
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented article from a peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact dermatitis and contact sensitization among enamellers and decorators in the ceramics industry
- Author:
- Motolese A, Truzzi M, Giannini A and Seidenari S
- Year:
- 1 993
- Bibliographic source:
- Contact Dermatitis 1993: 28: 59-62
Materials and methods
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 126 enamellers and 64 decorators from 5 factories underwent dermatological and allergological examination using occupational test series in order to evaluate the prevalence of dermatitis and contact sensitization, and to identify the most important sensitizing substances. Sodium tripolyphosphate was one of the substances tested.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentasodium triphosphate
- EC Number:
- 231-838-7
- EC Name:
- Pentasodium triphosphate
- Cas Number:
- 7758-29-4
- Molecular formula:
- H5O10P3.5Na
- IUPAC Name:
- pentasodium bis(phosphonatooxy)phosphinate
- Details on test material:
- - Name of test material (as cited in study report): Sodium tripolyphosphate
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed:
- Sex: 119 females and 71 males - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test
ADMINISTRATION
- Concentrations: To establish dilutions of sodium triployphosphate, 100 subjects undergoing standard patch testing were also patch tested with concentrations of 1 and 2%.
-Description of patch: Patch tests were applied with Finn Chambers (Epitest, Finland) on Scanpor tape (Norgesplaster, Norway)
- Removal of test substance: Removed after 2 days
- Testing/scoring schedule: 1 day after removal
Results and discussion
- Results of examinations:
-
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 1/190
Any other information on results incl. tables
No skin reactions to patch tests performed with sodium tripolyphosphate at different concentrations were observed in the subjects undergoing standard patch testing and no positive reactions to one or more allergens specific to the ceramics industry were discovered in healthy volunteers. (table 1).
Table 1: No. sensitizations to sodium tripolyphosphate used in the ceramics industry in enamellers and decorators:
Sodium tripolyphosphate |
Total 190 (100%) |
Enamellers 126 (100%) |
Decorators (100%) |
1 |
1 |
0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
