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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No GLP, no guideline and study as presented in the literature did not contain sufficient information to justify higher reliability.

Data source

Reference
Reference Type:
publication
Title:
The hydrolysis and excretion of polymeric phosphate
Author:
Gosselin RE, Rothstein A, Miller GJ and Berke HL
Bibliographic source:
Division of Pharmacology, Department of radiation biology, University of Rochester School of medicaine and dentristry, Rochester, N.Y.

Materials and methods

Objective of study:
excretion
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
STPP was injected intravenously. The urine was monitored for excretion of STPP and orthophosphate
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentasodium triphosphate
EC Number:
231-838-7
EC Name:
Pentasodium triphosphate
Cas Number:
7758-29-4
Molecular formula:
H5O10P3.5Na
IUPAC Name:
pentasodium bis(phosphonatooxy)phosphinate
Details on test material:
- Name of test material (as cited in study report): sodium tripolyphosphate
- Physical state: Crystalline
-
Radiolabelling:
no

Test animals

Species:
rat
Strain:
other: albino
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 270-310 g
- Fasting period before study: deprived of feed only after dosage
- Housing: all-glass metabolism cage
- Individual metabolism cages: yes
- Diet (e.g. ad libitum): occasionally they were allowed a standard chow ration during the experiment.
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:
intravenous
Vehicle:
water
Details on exposure:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): between 15.5 and 33.5 mg P per rat


Duration and frequency of treatment / exposure:
once
Doses / concentrations
Remarks:
Doses / Concentrations:
15.5 and 33.5 mg P per rat
No. of animals per sex per dose / concentration:
6
Control animals:
yes
Details on dosing and sampling:
PHARMACOKINETIC STUDY ( excretion)
- Tissues and body fluids sampled : urine,
- Time and frequency of sampling: frequency not stated. Mean excretion during 24 hr post dose was assessed.
- Other:


METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled : urine,
- Time and frequency of sampling:Mean excretion during 24 hr post dose was assessed.
- From how many animals: 22
- Method type(s) for identification: reference to a method by Meyerhof and Oesper, 1947.
- Limits of detection and quantification: not stated
- Other:

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
Average excretion of orthophosphate was higher than the average control value (14.9 mg ortho-P) (see table 1)

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
sodium orthophosphate

Any other information on results incl. tables

Table 1: Urinary excretion of polymer phosphorus in the rat

No. rats

Mean 24-hour excretion on % of dose

Labile P

Excess ortho-P

Total P

6

9

66

75

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
STPP was extensively hydrolysed to orthophosphate in rats.