Registration Dossier

Administrative data

Description of key information

According to EU regulation 1907/2006, Annex VII, column 2 an acute oral, dermal or inhalation study needs not to be conducted since Diphosphorus pentaoxide is classified as corrosive to the skin. 

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification

As above mentioned no acute toxicity studies have to be conducted with Diphosphorus pentaoxide due to its corrosive properties.

Diphosphorus pentaoxide is a hygroscopic solid which forms with moisture/water an aqueous solution of phosphorus oxyacids (primary hydrolysis) that are subject to further (secondary) hydrolysis to the end product phosphoric acid, H3PO4. The exposure to Diphosphorus pentaoxide under physiological conditions (aqueous system) will principally lead to local effects due to the strong corrosivity of the generated phosphoric acid. Consequently, the toxicity of Phosphoric acid/Diphosphorus pentaoxide, respectively is solely based on secondary effects of corrosivity. Furthermore, considering the corrosivity of the substance an acute exposure to Diphosphorus Pentaoxide is very unlikely to occur.

Based on the existing data no statement on classification/non-classification with reference to the acute toxicity can be made.