Registration Dossier

Diss Factsheets

Administrative data

Description of key information

According to EU regulation 1907/2006, Annex VII, column 2 an irritation study (skin/eye) needs not to be conducted since Diphosphorus pentaoxide is classified as corrosive to the skin. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on skin irritation/corrosion: highly corrosive

Effects on eye irritation: highly irritating

Justification for classification or non-classification

As above mentioned no irritation studies have to be conducted with Diphosphorus pentaoxide due to its corrosive properties.

Diphosphorus pentaoxide is a hygroscopic solid which forms with moisture/water an aqueous solution of phosphorus oxyacids (primary hydrolysis) that are subject to further (secondary) hydrolysis to the end product phosphoric acid, H3PO4. The exposure to Diphosphorus pentaoxide under physiological conditions (aqueous system) will principally lead to local effects due to the strong corrosivity of the generated phosphoric acid. Consequently, the toxicity of Phosphoric acid/Diphosphorus pentaoxide, respectively is solely based on secondary effects of corrosivity.

Based on the existing data the substance is subject to classification and labelling according to Directive 67/548/EEC and Regulation 1272/2008/EC regarding corrosive prpoerties. Diphosphorus pentaoxide has to be labeled with R35 – causes severe burns; H314 - causes severe skin burns and eye damage.