Registration Dossier
Registration Dossier
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EC number: 231-179-5 | CAS number: 7440-70-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Testing is not technically feasible because of Ca reactivity in air or water.Given that dissolution is widely considered to be required prior to percutaneous absorption, this may be interpreted as a likely indication of low bioavailability via the dermal exposure route.Based on exposure scenarios (chapter 9 of CSR) and risk characterization (chapter 10 of CSR) dermal exposure within industrial processes is taken into account and RMMs for local irritative effects already in place in the industry are sufficient for safe use of metallic calcium (section 7.10 of IUCLID, SCOEL (2008)).Calcium is abundantly available in different forms in the nature for human exposure and also in nutrition as well as distributed within the human body, as an essential element for various body functions calcium cannot be expected exhibit skin sensitization property.
Migrated from Short description of key information:
Sensitisation is not relevant for elemental calcium (or the Ca compounds) for the life-cycle of the metallurgical processes.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There is no information available for respiratory sensitisation. Testing is not technically feasible because of Ca reactivity in air or water. Given that dissolution is widely considered to be required prior to percutaneous absorption, this may be interpreted as a likely indication of low bioavailability via the dermal exposure route. Based on exposure scenarios (chapter 9 of CSR) and risk characterization (chapter 10 of CSR) inhalationl exposure within industrial processes is taken into account and RMMs for local irritative effects.already in place in the industry are sufficient for safe use of metallic calcium (section 7.10 of IUCLID, SCOEL (2008)).Calcium is abundantly available in different forms in the nature for human exposure and also in nutrition as well as distributed within the human body, as an essential element for various body functions calcium cannot be expected exhibit sensitization property.
Migrated from Short description of key information:
There is no evidence nor does the exposure of calcium raise concern for respiratory sensitization for the whole life-cycle of elemental calcium and subsequent calcium compounds.
Justification for classification or non-classification
There is no need for classification for sensitisation properties for elemental calcium.
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