Registration Dossier
Registration Dossier
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EC number: 265-193-8 | CAS number: 64742-90-1 A complex combination of hydrocarbons obtained as the residual fraction from the distillation of the products of a steam cracking process (including steam cracking to produce ethylene). It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly greater than C14 and boiling above approximately 260°C (500°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
Neurotoxicity
Administrative data
Description of key information
Toluene exposure can produce central nervous system pathology in animals after high oral doses. In humans neuropsychological effects have been reported, particularly when exposures are not well controlled. There was no association noted between either current or long-term (LWAE) toluene exposure and any of the cognitive outcomes measured, with 26ppm the mean current exposure and 45ppm the mean estimated lifetime exposure (Seeber et al, 2004).
Key value for chemical safety assessment
Additional information
There are no specific neurotoxicity data on any of the streams within the Fuel Oils category. Of the specific components toluene and styrene are recognised as having neurotoxic activity. These effects are discussed briefly in the section on repeated dose toxicity (5.6.3).
Justification for classification or non-classification
See section 5.6 for overall classification for repeated dose toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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