Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Toluene exposure can produce central nervous system pathology in animals after high oral doses.  In humans neuropsychological effects have been reported, particularly when exposures are not well controlled. There was no association noted between either current or long-term (LWAE) toluene exposure and any of the cognitive outcomes measured, with 26ppm the mean current exposure and 45ppm the mean estimated lifetime exposure (Seeber et al, 2004). 

Key value for chemical safety assessment

Additional information

There are no specific neurotoxicity data on any of the streams within the Fuel Oils category. Of the specific components toluene and styrene are recognised as having neurotoxic activity. These effects are discussed briefly in the section on repeated dose toxicity (5.6.3).

Justification for classification or non-classification

See section 5.6 for overall classification for repeated dose toxicity.