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EC number: 200-901-0 | CAS number: 75-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The key study (Bayer AG, 1984) tested under semi-occlusive conditions for four hours, in New Zealand white rabbits showed dichloro(dimethyl)silane to be corrosive. The conclusion was supported by findings in other studies. There are no reliable studies available for eye irritation; however, an old, non-guideline study (Mellon Institute, 1951) showed the test substance to be corrosive to the eyes. Further testing was not required as the test substance is classified as corrosive to skin. Although there was no specific study to investigate respiratory irritation, pathology examination in the key acute inhalation study (Dow Corning Corporation , 1997) showed signs of respiratory irritation/corrosion.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Hacking and Churchill Ltd, UK
- Age at study initiation: No data (needs translation)
- Weight at study initiation: 3.7 kg
- Housing: No data
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data (needs translation)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25
- Humidity (%): 40-60
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: November 1984 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- Four hours
- Observation period:
- 14 days
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: Flanks
- % coverage: No data (6 x 6cm)
- Type of wrap if used: Semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with water
- Time after start of exposure: four hours
SCORING SYSTEM: Draize - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: skin induration and pale yellow or light-red bordered skin at the application site was observed at 24 and 48 hours; at 72 hours necrosis of the whole application site was observed.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: skin induration and pale yellow or light-red bordered skin at the application site was observed at 24 and 48 hours; at 72 hours necrosis of the whole application site was observed.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: skin induration and pale yellow or light-red bordered skin at the application site was observed at 24, 48 and 72 hours; day 4 necrosis of the whole application site was observed.
- Irritant / corrosive response data:
- Eschar formation observed.
- Other effects:
- Signs of corrosion were observed from 1 hour to 14 days.
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- In a well conducted skin irritation study (reliability score 2) comparable to OECD 404, but not to GLP, dichlorodimethylsilane was corrosive to rabbit skin.
- Executive summary:
In a well conducted skin irritation study (reliability score 2) comparable to OECD 404, but not to GLP, 0.5 ml undiluted dichlorodimethylsilane was applied to the shaved flanks of six New Zealand white rabbits under a semi-occlusive dressing for four hours. The application site was then washed with water, and the site assessed for signs of irritation for 14 days. Eschar formation was noted, as a result of the corrosive activity of the test substance.
Reference
Corrosion was reported rather than scores being given.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Dichloro(dimethyl)silane is rapidly hydrolysed to dimethylsilanediol and hydrogen chloride in the presence of moisture. Therefore the signs of skin and eye irritation/corrosion noted in studies are considered due to the hydrolysis product HCl.
In the key skin irritation study (Bayer AG, 1984) dichloro(dimethyl)silane was tested under semi-occlusive conditions for four hours in New Zealand white rabbits and found to be corrosive to skin. This finding was consistent with those of supporting skin irritancy studies. There are no reliable studies available for eye irritation; however, an old, non-guideline study (Mellon Institute, 1951) showed the test substance to be corrosive to the eyes. Further testing was not required as the test substance is classified as corrosive to skin.
No information is available for respiratory tract irritation, in either animals or humans. However, the pathology examination in the key acute inhalation study (Dow Corning Corporation, 1997) revealed signs of respiratory irritation/corrosion.
Justification for classification or non-classification
Based on the available data dichloro(dimethyl)silane is classified 'Skin Corr. 1A' and 'Eye Dam. 1', with hazard statement H314 'Causes severe skin burns and eye damage’ according to Regulation (EC) No 1272/2008.
This is based on the skin irritation/corrosion data that show the test substance to be clearly corrosive to the skin. It is assumed that substances that are corrosive to the skin are also damaging to the eyes, so there is no separate labelling for the eyes. There are no specific data for respiratory irritation. However, the pathology examination in the key acute inhalation study revealed signs of respiratory irritation/corrosion. The test substance has the additional label 'EUH071 Corrosive to the respiratory tract'.
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