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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientific acceptable but short documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1965
Report date:
1965

Materials and methods

Principles of method if other than guideline:
The test substance was dissolved in ethanol/lutrol (1:1) and dynamically sprayed into an inhalation apparatus. For each concentration 20 male rats were used. Duration of exposure was 4 hours and the post exposure observation time 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propylidynetrimethanol
EC Number:
201-074-9
EC Name:
Propylidynetrimethanol
Cas Number:
77-99-6
Molecular formula:
C6H14O3
IUPAC Name:
2-ethyl-2-(hydroxymethyl)propane-1,3-diol
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
no further data

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
other: ethanol/lutrol (1:1)
Details on inhalation exposure:
the test substance was disolved in ethanol/lutrol (1:1) and dynamically sprayed into an inhalation apparatus; no further data
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
0.59 mg/liter or 0.85 mg/liter (analytical)
2.5 mg/liter or 5.0 mg/liter (nominal)
No. of animals per sex per dose:
20 male rats per concentration
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs, body weight
Statistics:
no data - all animals survived

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
> 0.85 mg/L air
Based on:
other: no mortality was observed
Exp. duration:
4 h
Remarks on result:
other: none of the rats died
Mortality:
none of the animals died
Clinical signs:
other: no symptoms of poisoning were reported
Body weight:
0.58 mg/l: start 235 g ,end 254 g (avarage weight)
0.85 mg/l: start 206 g ,end 239 g (avarage weight)
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

No data.

Applicant's summary and conclusion

Executive summary:

20 male rats were whole body exposed to 590 mg/m³ or 850 mg/m³ (analytical) trimethylolpropane for 4 hours and observed for 14 days. Nominal concentrations were 2.6 und 5 g/m³. The substance was disolved in ethanol/lutrol (1:1) and dynamically sprayed into an inhalation apparatus. No mortalities and no clinical signs of toxicity were reported up to and including the highest exposure level of  850 mg/m³.The LC50 value could not be determined exactly and is supposed to be > 850 mg/m³.

(Bayer AG, 1965).