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Physical & Chemical properties

Water solubility

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Description of key information

The solubility of HFC 125 in water at 25°C under atmospheric pressure has been estimated by the Henry's law constant experimentally derived by Arlt and co-workers.

Key value for chemical safety assessment

Water solubility:
430 mg/L
at the temperature of:
25 °C

Additional information

HFC-125 solubility in water at 25°C has been determined in 3 independent studies:

  • Abraham et al. (2001) calculated an Ostwald coefficient (air-water at 25 °C) of -1.059 for HFC 125 starting from an experimentally derived HLC. The water solubility under atmospheric pressure calculated form the Ostwald coefficient result 430 mg/l and 295 mg/l at 25°C and 37°C, respectively.
  • Miguel et al. (2000) indirectly determined the water solubility by measuring the change in the volume of HFC 125 in contact with a known volume of water at constant temperature and pressure (25°C and 101.325 kPa). The solubility under these experimental conditions resulted 3890 mg/l.
  • DuPont (2004) determined the mutual solubility of water and HFC 125 under saturation conditions (i.e. the equilibrium among the 2 liquid phases and the gas phase. Under these conditions, HFC 125 solubilised in water is in equilibrium with a partial pressure equivalent to HFC 125 vapour pressure at 25 °C. Under this experimental conditions, a concentration of about 4600 mg/l was measured for HFC 125.

The Henry's law equation (Vp * Mw/ws = constant at constant temperature) demonstrates that the data from Abraham et al. is fairly consistent with the Dupont data:


(101325*120.02)/430 ≈ (1375800 * 120.02)/4600,


Whereas the Miguel et al. result seems to significantly overestimate the water solubility of HFC 125 under atmospheric pressure. For this reason, the study result from Abraham et al (2001) was selected as the most reliable.

Furthermore, the solubility of HFC 125 in physiological saline at 37°C was experimentally determined in 2 independent studies to be in the range 260 -350 mg/l (Ernstgard et al., 2010; Eger et al., 1994). Those results are in good agreement with the value of 295 mg/l calculated by Abraham et al., 2001 at 37°C, confirming then the validity of the Abraham's study.