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EC number: 206-557-8 | CAS number: 354-33-6
No acute and chronic ecotoxicity data are available for HFC 125.
Acute aquatic toxicity
In view of the nature of the substance, the performance of aquatic ecotoxicity studies would feasible only in close system and would likely not be indicative of the natural exposure conditions. The assessment of the possible aquatic toxicity of HFC 125 has been carried out by considering available data on structurally analogue substances.
The analogue approach for the HFC category is justified and documented in the position paper "Use of categories approach in environmental hazard assessment of hydrofluorocarbons (HFCs) and hydrochlorofluorocarbons (HCFCs)", attached in the Endpoint Summary in Section 6 of the Technical Dossier (Ecotoxicological Information).
Experimental data for acute toxicity on fish are available for HFC 134a (1,1,1,2 -tetrafluoroethane), HFC 245fa (1,1,1,3,3-pentafluoropropane) and HFC 365mfc (1,1,1,2,2 -pentafluorobutane). In all cases, a low acute toxicity to fish was observed (LC50 = 450 mg/l for HFC 134a; LC50 > 100 mg/l for HFC 245fa and LC50 >200 mg/l for HFC 365mfc).
Similar results were obtained with the same structural analogues in the acute toxicity studies on Daphnia magna (EC50 = 980 mg/l for HFC 134a; EC50 > 100 mg/l for HFC 245fa and EC50> 200 mg/l for HFC 365mfc).
Finally, the toxicity on algae was estimated by considering available experimental data on HFC 245fa and HFC 365mfc and QSAR estimation carried out for HFC 32 (difluoromethane). Also in this case all considered results lead to an expected low toxicity for HFC 125 (EC50 > 118 mg/l for HFC 245fa; EC50 > 114 mg/l for HFC 365mfc and EC50 = 142 mg/l for HFC 32).
Chronic aquatic toxicity: HFC 125 is not emitted into the aquatic compartment during its manufacturing and uses. Besides, a negligible partitioning in the aquatic compartment is expected following the emission of HFC 125 in the environment. For those reasons, no chronic toxicity to aquatic biota is expectable for HFC 125.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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